What moved in your trials overnight.
Pick a sponsor or disease. Every morning DataLookout compares each of their ClinicalTrials.gov records with yesterday's and sends you the differences: status, dates, enrollment, endpoints, sites, and the reason a trial stopped.
Free plan is free for good: one sponsor, one disease, no card. Paid plans from $49/month.
From the sweep of 7 November 2026930 changes on 506 trials
2026-11-07
critical
Trial terminated
Trial terminated: Business reasons and not based on any safety concerns.
Trial terminated: Business reasons and not based on any safety concerns.
2026-11-05
critical
Trial terminated
Trial terminated: Dose-finding stage has been completed, and dose-expanding stage was not conducted due to design amendment.
Final enrollment: 19 participants (planned 180)
Primary completion date changed from estimate of Jul 2026 to Jul 31, 2025
Trial terminated: Dose-finding stage has been completed, and dose-expanding stage was not conducted due to design amendment.
Final enrollment: 19 participants (planned 180)
Primary completion date changed from estimate of Jul 2026 to Jul 31, 2025
2026-11-05
notable
Enrollment reduced: 20 → 12 participants
Primary endpoint(s) modified
Interventions modified
Primary endpoint(s) modified
Interventions modified
2026-11-06
notable
Enrollment reduced: 528 → 179 participants
Recruitment opened
Recruitment opened
2026-11-03
notable
Enrollment reduced: 105 → 65 participants
Primary completion pushed from Jan 2029 to Oct 2029
Study completion pushed from Feb 2029 to Oct 2031
Primary completion pushed from Jan 2029 to Oct 2029
Study completion pushed from Feb 2029 to Oct 2031
2026-11-07
notable
Primary endpoint(s) modified
Enrollment closed, study ongoing
Enrollment closed, study ongoing
Six real entries from the seven days to 7 November 2026, exactly as detected. Every value is checkable on ClinicalTrials.gov by NCT number.
ClinicalTrials.gov keeps every version. Nobody has time to read them.
A registry record can change quietly: a completion date slides a year, an endpoint is reworded, a stopped trial gets its reason weeks later. The registry stores each version but shows you one trial at a time. DataLookout reads the versions for the sponsors and diseases you name and reports only what differs, with the old value next to the new one.
- Overall statusrecruiting, suspended, terminated, completedThe change most people want first. Terminations and suspensions are marked critical.
- Primary completion dateand study completion dateThe readout clock. A push of 30 days or more is flagged; the size of the shift is shown as a floor.
- Enrollment countCuts often precede a termination. Increases usually mean an expansion.
- Why the trial stoppedfree text from the sponsorQuoted verbatim, because it typically arrives after the status flips.
- Primary endpointsRewrites are flagged, not interpreted. You read the before and after.
- Phase, arms, sites, sponsorand new trials registeredPhase moves, arm and site counts, a change of lead sponsor, and any new record from a sponsor you watch or in a disease you watch.
Trials at Risk
The ones slipping while still marked "Recruiting."
A trial rarely announces trouble. It pushes its date, trims enrollment, and rewrites an endpoint, each edit small enough to pass. Trials at Risk collects those signals across your watchlist and ranks the trials that show more than one.
Full list on Pro. Free shows the top 2 trials.
2026-08-15
notable
Primary completion pushed 27 months: 2029-01-23→2031-04-30
2026-08-15
minor
Primary endpoints rewritten in the same update
2026-08-15
minor
Enrollment raised 470→580
2026-08-15
minor
Status unchanged: Recruiting
Three signals in one registry update, detected 15 August 2026. Still recruiting on the record.
How it works
Three steps, then it runs without you. Everything is drawn from ClinicalTrials.gov's official API, unmodified.
- Name a sponsor or diseaseSearch 150,000+ trials by sponsor, condition, or NCT number. Add what matters to your watchlist, or save any search (a phase, a status, a start-date window) and get a daily or weekly digest when its results change. Adding a company turns your watchlist into a running drug pipeline tracker for the trials it has active.
- We compare, every morningEach watched record is diffed against yesterday's version across the fields above. Each change is marked Stopped, Notable or Minor. That is automated clinical trial monitoring, and it runs whether or not you log in.
- You read the differencesA daily or weekly email covering your watchlist and saved searches, plus a dashboard where each change can be marked read or done, with the change history, a landscape analysis of every sponsor active in a disease, and Trials at Risk.
Pricing
Start free, no card. Cancel any time from your account page.
| Free$0 forever | Pro$49 / month, or $490 / year | |
|---|---|---|
| Watchlist | 1 sponsor + 1 disease | 10 sponsors + 10 diseases |
| Saved searches in your email digest | 1 | 10 |
| Tracked individual trials | 5 | 25 |
| Daily change detection | Yes | Yes |
| Email digest (watchlist + saved searches) | Daily or weekly | Daily or weekly |
| Trials at Risk | Top trial only | Full list |
| Completions calendar | Preview | Full |
| Landscape reports | Preview | Full |
| Pipeline Pulse | Yes | Yes |
| CSV export | — | Yes |
| Support | — | |
| Start free | Sign up for Pro |
Search and browse 150,000+ trials on every plan. Prices in USD, billed monthly or yearly.
FAQ
Frequently asked questions
Is the free plan really free?
Yes. The free plan is free forever. You get 1 sponsor and 1 disease watchlist with full change detection, and you can search and browse 150,000+ trials with no time limit. Upgrade to Pro when you want more.
How is this different from searching ClinicalTrials.gov directly?
ClinicalTrials.gov keeps a full version history for every trial and offers RSS feeds for new and updated studies. What it does not do is compare versions across a set of sponsors or diseases and tell you which field moved and from what value. DataLookout does that comparison for your watchlist every morning.
What is change detection?
DataLookout takes daily snapshots of the trials it tracks and compares thirteen fields on each one. When a trial changes status, advances phase, updates enrollment, moves a completion date, modifies a primary endpoint, changes its interventions, adds sites, gains a stated reason for stopping, or publishes its results, the change is recorded with the old and new value and marked Stopped, Notable or Minor.
What is Trials at Risk?
Trials at Risk flags the active trials on your watchlist showing warning signs: a primary completion date pushed out by 30 or more days, enrollment cut, or a primary endpoint changed. Trials with several signals rank highest. Free accounts see the top trial; Pro sees the full list.
Will I be notified about new trials, not just changes?
Yes. When a sponsor on your watchlist registers a new trial on ClinicalTrials.gov, or a new sponsor appears in a disease you watch, it appears in your next email digest as a New Trial entry, separate from changes to existing trials.
What are Landscape Reports and Pipeline Pulse?
A Landscape Report is a full breakdown of a disease area: the most active sponsors grouped by phase, a phase distribution chart, recent protocol changes, and new entrants. Pipeline Pulse ranks 88 disease areas by trial momentum, a composite of Phase 3 density, new starts, and new sponsor entrants.
Name one sponsor or disease. Read tomorrow's differences.
Free forever for one of each. No card.