Leukemia clinical trials in 2026: a rapidly evolving landscape
Leukemia encompasses four major disease subtypes, AML, ALL, CLL, CML, each with a distinct trial ecosystem. The live trial data on this page shows the current count of active leukemia trials on ClinicalTrials.gov, spanning Phase 1 through Phase 3 across all subtypes. The common thread in 2025–2026 is the rapid proliferation of targeted combination strategies, bispecific antibodies, and next-generation CAR-T approaches generating dozens of new trials each quarter.
| Subtype | Active Trials | Phase 3 Active | Primary Drug Classes |
|---|---|---|---|
| AML | 242 | 17 | FLT3i, IDH1/2i, venetoclax combos, menin inhibitors |
| ALL | 151 | 14 | Blinatumomab, CAR-T (CD19/CD22), inotuzumab |
| CLL | 143 | 22 | BTK inhibitors, venetoclax, BTK degraders (PROTACs) |
| CML | 32 | 3 | Asciminib (STAMP inhibitor), TKI discontinuation, TFR |
For hematology-focused pharma, biotech, and research teams, manually tracking new trials across all leukemia subtypes on ClinicalTrials.gov is increasingly impractical. A daily automated digest cuts through the noise.
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| Trial | Warning signs | Status |
|---|---|---|
| Phase I/II Open-label Study Evaluating The Safety And Efficacy of Concomitant… NCT06762431 | Primary completion moved at least 5 months later Primary endpoint added Enrollment reduced 60% | Recruiting |
142 more on the Trials at Risk page. See which trials →
Phase 2 and Phase 3 trials with a primary completion date in the next 180 days, as ClinicalTrials.gov estimates it today. Active trials only.
| Trial | Scheduled | Phase |
|---|---|---|
| Study to Evaluate the Safety and Efficacy of Daratumumab and Carfilzomib-based… NCT06140966 | Oct 20, 2026 · Estimated | Phase 2 |
166 more on the Completions page. See the calendar →
Acute myeloid leukemia (AML): targeted therapy combinations
AML carries the highest trial volume of any leukemia subtype, with Phase 3 programs enrolling or in follow-up alongside a deep early-phase pipeline. The defining feature of the 2025–2026 AML landscape is the convergence of multiple targeted agents that can now be combined: FLT3 inhibitors, IDH inhibitors, venetoclax, and menin inhibitors are each approved or late-stage, and the field is now studying how to sequence and combine them to deepen remissions and overcome resistance. See the full AML trial tracker →
Menin inhibitors: the newest approved class
Revumenib (Syndax) became the first menin inhibitor approved by the FDA in 2024 for relapsed/refractory AML with KMT2A rearrangement. Ziftomenib (Kura Oncology) is in active Phase 3 development (NCT07007312) testing combinations with venetoclax+azacitidine or 7+3 induction chemotherapy in NPM1-mutant and KMT2A-rearranged AML. The menin-KMT2A-MLL axis represents the most clinically validated new dependency in AML discovered in the past five years.
FLT3 inhibitors: MRD-guided maintenance
Midostaurin and gilteritinib established FLT3 inhibition as standard therapy. The frontier in 2026 is MRD-guided maintenance after allogeneic transplant, a Phase 3 trial (NCT07463651) is directly comparing gilteritinib vs. sorafenib in FLT3+ patients based on post-transplant MRD status. Next-generation FLT3 inhibitors with improved selectivity and CNS penetration are advancing in Phase 1/2.
BCL-2 inhibitor combinations
Venetoclax plus azacitidine is standard frontline therapy for unfit patients. The current Phase 3 wave (NCT04628026, NCT07396480) tests whether adding venetoclax to standard induction and transplant conditioning improves outcomes in fit patients. The parallel question is how to sequence or combine venetoclax with FLT3i, IDH1/2i, and menin inhibitors in patients who are simultaneously eligible for multiple targeted agents.
IDH1/IDH2 inhibitors
Ivosidenib and enasidenib established single-agent activity in IDH-mutant R/R AML. Ongoing trials test these agents combined with venetoclax, azacitidine, and intensive chemotherapy in newly diagnosed and R/R settings. An oral azacitidine prodrug (cedazuridine/azacitidine; ASTX030, NCT04256317, Phase 3) is actively enrolling in myeloid neoplasms and may reshape how azacitidine-backbone regimens are delivered.
Acute lymphoblastic leukemia (ALL): bispecifics and CAR-T
ALL carries a broad active pipeline with multiple Phase 3 programs. The bispecific antibody blinatumomab (CD3×CD19) and CAR-T therapies have transformed relapsed/refractory B-cell ALL, the 2025–2026 trial landscape is now moving these proven approaches earlier in the treatment sequence and into pediatric settings. See the full ALL trial tracker →
- Blinatumomab in frontline therapy: NCT03914625 (NCI Phase 3) testing blinatumomab combined with standard chemotherapy in newly diagnosed B-ALL, results pending with potential to reshape induction protocols
- Inotuzumab ozogamicin earlier: NCT03959085 (Children's Oncology Group Phase 3) adding inotuzumab to post-induction chemotherapy in pediatric B-ALL with high MRD after induction
- CAR-T in earlier lines: Programs now enrolling in post-frontline relapse (rather than third-line only), with MRD-positive patients being studied as a bridge-to-transplant or transplant-replacement strategy
- T-cell ALL: CAR-T programs targeting CD7, CD1a, and other T-ALL antigens in Phase 1/2, the frontline remains chemotherapy-intensive but targeted approaches are advancing
- Philadelphia chromosome-positive ALL: Ponatinib/blinatumomab combinations (NCT04530565, NCI Phase 3) now actively active, not recruiting for Ph+ ALL
- MRD-directed therapy: Multiple Phase 3 trials use MRD as a guide to intensify or de-escalate, the goal is curing more patients while reducing long-term chemotherapy toxicity
Chronic lymphocytic leukemia (CLL): BTK inhibitor evolution
CLL carries a deep Phase 3 pipeline, reflecting an extremely active post-BTKi drug development environment. BTK inhibitors (ibrutinib, acalabrutinib, zanubrutinib) transformed CLL; the current question is what happens when those agents stop working. See the full CLL trial tracker → | BTK inhibitor pipeline overview →
- Non-covalent BTK inhibitors: Pirtobrutinib (Lilly) is approved for C481S-mutated BTK-resistant disease; nemtabrutinib (Merck) is in Phase 3 trials, both bind the BTK active site without forming a covalent bond, bypassing the primary resistance mechanism
- BTK degraders (PROTACs): BGB-16673 (BeiGene) has 5 Phase 3 trials currently enrolling, the first BTK PROTAC in late-stage development, designed to degrade rather than just inhibit BTK and overcome both C481S and alternative resistance mutations
- Fixed-duration venetoclax + BTKi: Multiple Phase 3 trials testing time-limited combination regimens in treatment-naive CLL, the goal is durable MRD-negative remissions without indefinite therapy
- CAR-T and bispecifics for double-refractory disease: Patients who have failed both BTK inhibitors and venetoclax represent a high unmet need; CD19/CD20 CAR-T and bispecific antibodies (anti-CD20×CD3) are entering Phase 2/3 for this population
- MRD-guided treatment-free remission: Landmark trials showing that venetoclax-based regimens can achieve MRD-negativity and support treatment discontinuation are spawning a new generation of fixed-duration combination trials
Chronic myeloid leukemia (CML): TKI optimization
CML has the smallest trial volume of the four major subtypes, reflecting a disease that is now largely managed with standard TKI therapy (imatinib, dasatinib, nilotinib, bosutinib). Active trial areas include: deep molecular response optimization for treatment-free remission (TFR) eligibility, asciminib (STAMP inhibitor targeting the myristoyl pocket) now approved and moving into earlier-line testing, ponatinib combinations for T315I gatekeeper mutations, and approaches to CML blast crisis which has outcomes similar to de novo AML.
Who monitors leukemia clinical trials?
- Hematology-oncology pharma teams at companies with AML, ALL, or CLL programs tracking competitor trial activity
- Clinical development leaders designing new combination trials needing current competitive landscape data
- Medical science liaisons and medical affairs needing current knowledge of enrollment status and new trial openings
- Healthcare investors covering hematology-focused biotech companies
- Academic hematologists who refer patients to relevant trials and need to know what's enrolling nearby
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2159 active trials, 1244 recruiting.
Industry sponsors run 411 of these trials. The rest are run by universities, hospitals, government bodies and other non-commercial sponsors. The table below lists the 5 largest of 199.
| Top industry sponsor | Active trials |
|---|---|
| Novartis Pharmaceuticals | 25 |
| AstraZeneca | 19 |
| AbbVie | 18 |
| Johnson & Johnson / Janssen | 12 |
| Ascentage Pharma Group Inc. | 11 |
| Trial | Status | Latest tracked change | Seen |
|---|---|---|---|
| Whole Genome Sequencing (ChromoSeq®) for Acute Lymphoblastic Leukemia (ALL)… NCT07313592 | Recruiting | Interventions modified | 2026-10-10 |
| Ziftomenib in Combination With Chemotherapy for Children With… NCT06376162 | Recruiting | Completion pushed from Jan 2027 to Mar 2033 | 2026-10-10 |
| A Study of CD19 Targeted CAR T Cell Therapy in Pediatric Patients With Relapsed… NCT06173518 | Recruiting | Trial sites expanded: 11 → 14 locations | 2026-10-10 |
| MB-CART19.1 r/r CD19+ B-cell Malignancies (BCM) NCT03853616 | Active, Not Recruiting | Completion pushed from Sep 2026 to Nov 2026 | 2026-10-10 |
| Biomarkers in Patients With Anemia-Induced Thrombocytopenic Bleeding NCT06947044 | Active, Not Recruiting | Completion pushed from Nov 1, 2026 to Feb 1, 2027 | 2026-10-10 |
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