Phases, active trials: Phase 1: 32, Phase 2: 46, Phase 3: 71, Other: 77
Bristol-Myers Squibb's clinical pipeline is defined by its foundational immuno-oncology franchise, Opdivo (nivolumab, PD-1) and Yervoy (ipilimumab, CTLA-4), plus a growing cell therapy portfolio. The Opdivo + Yervoy combination remains one of the most broadly applied IO regimens in oncology, with ongoing trials across virtually every solid tumor type. In hematology, Breyanzi (lisocabtagene maraleucel) for large B-cell lymphoma and Abecma (idecabtagene vicleucel) for multiple myeloma represent BMS's CAR-T franchise, with active trials moving these therapies into earlier lines. Their cardiovascular drug mavacamten (Camzyos) and factor XIa inhibitor milvexian are advancing in a rejuvenated cardiovascular pipeline.
- Immuno-oncology (PD-1/CTLA-4)
- Cell therapy (CAR-T, lymphoma, myeloma)
- Hematology / combinations
- Cardiovascular (mavacamten, factor XIa)
- Fibrosis / inflammation
- Opdivo (nivolumab): PD-1, pan-tumor IO
- Yervoy (ipilimumab): CTLA-4, IO combination
- Breyanzi (lisocabtagene maraleucel): CD19 CAR-T, B-cell lymphoma
- Abecma (idecabtagene vicleucel): BCMA CAR-T, myeloma
- Reblozyl (luspatercept): erythroid maturation, MDS/beta-thal
- Camzyos (mavacamten): cardiac myosin, HCM
A primary completion date pushed out, enrollment cut, or a primary endpoint changed in the last 90 days. Active trials only.
| Trial | Warning signs | Status |
|---|---|---|
| Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells NCT03435796 | Primary completion moved at least 6 years 5 months later | Recruiting |
12 more on the Trials at Risk page. See which trials →
Phase 2 and Phase 3 trials with a primary completion date in the next 180 days, as ClinicalTrials.gov estimates it today. Active trials only.
| Trial | Scheduled | Phase |
|---|---|---|
| A Study to Evaluate Safety, Drug Levels and Effectiveness of CC-92480… NCT05372354 | Oct 12, 2026 · Estimated | Phase 1/2 |
14 more on the Completions page. See the calendar →
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Start monitoring free| Condition / indication | Active trials |
|---|---|
| Multiple Myeloma | 13 |
| Healthy Volunteers | 9 |
| Melanoma | 7 |
| Schizophrenia | 7 |
| Non-Small Cell Lung Cancer | 6 |
| Plaque Psoriasis | 6 |
| Psoriasis | 6 |
| Advanced Solid Tumors | 5 |
BMS's PD-1/CTLA-4 combination program generates dozens of new combination trials annually. For any company developing new IO agents or solid tumor therapies, tracking when BMS starts a new Opdivo+Yervoy+X trial in your indication is critical competitive intelligence.
DataLookout monitors ClinicalTrials.gov daily and surfaces changes to Bristol-Myers Squibb's registered studies: new trial registrations, status transitions (for example "Not yet recruiting" to "Recruiting"), site additions, and protocol amendments. This is the intelligence layer that bridges the gap between quarterly investor calls and day-to-day pipeline developments.
- Sponsor normalization: Bristol-Myers Squibb may register trials under multiple legal entity names. DataLookout normalizes all related entities to a single canonical sponsor for complete pipeline coverage.
- Daily updates: ClinicalTrials.gov is queried each morning. New registrations and updates appear in that day's digest.
- Field-level change detection: Status changes, enrollment updates, and site additions are detected and surfaced, not just new registrations.
- Phase filtering: Focus on Phase 3 pivotal trials, Phase 2 proof-of-concept studies, or all phases for comprehensive coverage.
- Indication filtering: Combine sponsor monitoring with indication keywords to focus on the therapeutic areas relevant to your business.
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Get started free| Trial | Status | Latest tracked change | Seen |
|---|---|---|---|
| Study of Izalontamab Brengitecan (BMS-986507) in Combination With Osimertinib… NCT07680790 | Recruiting | Trial sites reduced: 208 → 201 locations | 2026-10-09 |
| Asia Myelodysplastic Syndrome (MDS) Registry NCT07355478 | Recruiting | Recruitment opened | 2026-10-09 |
| A Study to Assess the Safety, Tolerability, Efficacy, and Drug Levels of… NCT06035497 | Active, Not Recruiting | Primary completion date changed from estimate of Jan 30, 2027 to Aug 11, 2026 | 2026-10-08 |
| A Phase 1 Study of Navlimetostat Tablet Formulations NCT07544628 | Recruiting | Primary completion pushed from Aug 31, 2026 to Nov 2, 2026 | 2026-10-08 |
| A Study of Navlimetostat (BMS-986504) Drug Interactions and Food Effect in… NCT07800897 | Recruiting | Start date changed from estimate of Aug 26, 2026 to Aug 31, 2026 | 2026-10-06 |
Each trial page shows every change DataLookout has recorded for that trial.